Discordance between meta-analyses and large-scale randomized, controlled trials: examples from the management of acute myocardial infarction

Article Abstract:

Combining the results of small scientific studies, known as a meta-analysis, may be useful in developing, but not in proving, theories. Researchers considered meta-analytic studies regarding the use of nitrate and magnesium for treating heart attack patients. Two large studies found that the use of nitrate therapy did not reduce mortality for patients who had experienced heart attacks, while a meta-analysis of seven smaller studies found a reduction in mortality from nitrates. Similarly, a meta-analysis of eight studies found that magnesium therapy reduced mortality by 35% over no therapy, but a large study did not find any benefit from magnesium. Combining study results in a meta-analysis may bring up interesting findings to be studied further, but should not define treatment.

Health aspects, Care and treatment, Evaluation, Clinical trials, Meta-analysis, Nitrates, Magnesium, Magnesium (Metal)

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Factor V Leiden mutation and the risks for thromboembolic disease: a clinical perspective

Article Abstract:

Although the coagulation disorder associated with the factor V Leiden gene mutation is associated with a greater risk of forming blood clots in the veins, screening for this disease may have limited use without further studies on the treatment of the condition. Literature associated with factor V Leiden was reviewed to determine the risk of thromboembolism in these individuals. The risk was increased, especially in people with two copies of the mutation. However, the risk of the preventative treatment, long-term anticoagulation therapy, may be equal to or greater than that from thromboembolism except in those with a family or personal history.

Analysis, Complications and side effects, Blood clotting disorders, Blood coagulation disorders, Medical screening, Health screening, Thromboembolism

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Evaluating Novel Cardiovascular Risk Factors: Can We Better Predict Heart Attacks?

Article Abstract:

Many patients who suffer heart attack lack the traditional risk factors, and researchers are searching for physiologic markers that may indicate which patients are at high risk for cardiovascular disease and heart attack. Promising substances in the blood that may be associated with heart attack risk include lipoprotein(a), total plasma homocysteine, fibrinolytic capacity, fibrinogen, and high-sensitivity C-reactive protein. Determination of the predictive value of these factors, and the ability to screen for them, is being investigated.

United States

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