Discrepancy between self-reported and actual caloric intake and exercise in obese subjects
Article Abstract:
Self-reported diet resistance may be due to an underreporting of food intake and an overestimation of physical activity. In a study to see whether abnormally low energy expenditure and underreporting could explain a failure to lose weight among obese subjects on a low-calorie (under 1200 calories) diet, 90 obese patients were compared. Group one was made up of ten subjects with a history of diet resistance and group two consisted of 80 patients with no diet resistance history. Total energy expenditure from exercise, digestion and body heat was not significantly different between the two groups, ruling out low energy expenditure as an explanation for diet resistance. However, patients in group one underreported caloric intake by an average of 47% and overestimated activity by an average of 51%. Patients in group two also misreported their intake and expenditure but not to the extent of patients in group one.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 1992
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Weight Control and Risk Factor Reduction in Obese Subjects Treated for 2 Years With Orlistat: A Randomized Controlled Trial
Article Abstract:
The drug orlistat appears to be effective in promoting weight loss. This drug reduces fat absorption in the intestines by about 30%. Researchers randomly assigned 880 obese patients to take orlistat or a placebo in addition to a reducing diet. Two different dosages of orlistat were tested: 120 milligrams (mg) three times a day or 60 mg three times a day. More patients in the orlistat group lost weight in the first year compared to the placebo group. Patients taking the higher dose were less likely to regain the weight during the second year of the study.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 1999
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Recombinant variant of ciliary neurotrophic factor for weight loss in obese adults: a randomized, dose-ranging study
Article Abstract:
A genetically engineered form of ciliary neurotrophic factor may be an effective treatment for obesity, according to a study of 173 obese men and women. Ciliary neurotrophic factor is a natural substance produced in the brain that can cause weight loss. The mechanism for this weight loss was not understood until it was discovered that ciliary neurotrophic factor can behave like leptin, a hormone involved in maintaining body weight.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 2003
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