Diverse compounds mimic Alzheimer disease - causing mutations by augmenting Abeta42 production
Article Abstract:
A number of compounds that raise Abeta42, which is linked to the development of Alzheimer disease, are identified. Some of the more potent Abeta42-raising agents identified are fenofibrate, an antilipidemic agent, and celecoxib, a COX-2-selective nonsteroidal anti-inflammatory drug (NSAID).
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2005
User Contributions:
Comment about this article or add new information about this topic:
Anti-cancer activity of targeted pro-apoptotic peptides
Article Abstract:
Researchers have developed a pro-apoptotic peptide that targets new blood vessels produced by tumors and destroys them by disrupting mitochondrial membranes. The peptide is non-toxic outside of cells but induces cell death when internalized.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 1999
User Contributions:
Comment about this article or add new information about this topic:
A second cytotoxic proteolytic peptide derived from amyloid beta-protein precursor
Article Abstract:
Researchers describe a peptide unrelated to beta amyloid that is produced from amyloid beta-protein precursor. It is produced by caspases and induces neuronal cell death.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2000
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Association of nitrotyrosine levels with cardiovascular disease and modulation by statin therapy. Association Between Myeloperoxidase Levels and Risk of Coronary Artery Disease
- Abstracts: A founder mutation in presenilin 1 causing early-onset Alzheimer disease in unrelated Caribbean Hispanic families
- Abstracts: Antiplatelet therapy for ischemic heart disease. The Eisenmenger syndrome in adults. Congenital heart disease in adults, part 1
- Abstracts: Characteristics and prognostic implications of myosin missense mutations in familial hypertrophic cardiomyopathy
- Abstracts: Another wage-round victory but are we winning the war? NHS stalwarts starved of recognition. Nurse consultants to get 42,000 pounds sterling