Done density in non-insulin-dependent diabetes mellitus: the Rotterdam study
Article Abstract:
Men and women with non-insulin-dependent diabetes mellitus (NIDDM) may have higher bone mineral density than non-diabetic persons. A population-based study in the Netherlands found that 243 men and 335 women with NIDDM had greater bone mineral density at four locations in the lumbar spine and hip than people without NIDDM. Women with NIDDM had fewer fractures not involving the spine. Adjustments were made for the effects of age, body mass index, waist-to-hip ratio, thiazide use, loop diuretics, estrogens, smoking, blood creatinine levels, and impairment of activities of daily living. Why bone mineral density is greater in persons with NIDDM is unknown, but it may be caused by increased insulin levels stimulating a buildup of minerals in bone tissue.
Publication Name: Annals of Internal Medicine
Subject: Health
ISSN: 0003-4819
Year: 1995
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Polymorphonuclear leukocytes in non-insulin-dependent diabetes mellitus: abnormalities in metabolism and function
Article Abstract:
High levels of blood glucose in non-insulin-dependent diabetics may initiate an influx of calcium into polymorphonuclear leukocytes (PMNLs). This influx may damage the ability of cells to destroy foreign material, which may lead to chronic kidney failure. Researchers measured calcium and adenosine triphosphate (ATP) levels, and the ability of cells to kill foreign material, in PMNLs of 34 patients with non-insulin-dependent diabetes (NIDDM) and of 22 normal subjects. PMNLs of NIDDM patients had higher calcium levels, lower ATP levels and a reduced ability to kill foreign matter. Glyburide treatment reduced the calcium level in PMNLs to normal. Treatment with calcium channel blockers may prevent the process of calcium influx into PMNLs.
Publication Name: Annals of Internal Medicine
Subject: Health
ISSN: 0003-4819
Year: 1995
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Association of fibrinogen with glycemic control and albumin excretion rate in patients with non-insulin-dependent diabetes mellitus
Article Abstract:
Elevated levels of fibrinogen may be prevalent among people with non-insulin-dependent diabetes mellitus (NIDDM). Researchers analyzed the levels of fibrinogen in plasma and the link between fibrinogen levels with hemoglobin A1c and albumin excretion in 1574 NIDDM patients in Italy. NIDDM patients were found to have an increased risk of high fibrinogen levels, which may in turn predispose them to cardiovascular disease. Elevated fibrinogen levels were associated with elevated albumin excretion rates and with elevated hemoglobin A1c values. Elevated fibrinogen levels have been linked with buildup of fatty deposits in the arteries.
Publication Name: Annals of Internal Medicine
Subject: Health
ISSN: 0003-4819
Year: 1996
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