Early ibuprofen administration to prevent patent ductus arteriosus in premature newborn infants

Article Abstract:

Early administration of ibuprofen to premature infants may prevent patent ductus arteriosus (PDA). PDA occurs when the channel between the pulmonary artery and the descending aorta remains open, rather than closing as it normally should. Researchers administered a single intravenous dose of ibuprofen with 3 hours of birth to 11 premature infants, three doses to 12 infants and a placebo to 11 infants. Echocardiograms within the first 3 days and again at 7 and 21 days revealed that none of the infants who received three doses developed PDA, while six of those that received a single dose did and seven of the infants on placebo did. Infants who received three doses had better lung function and spent less time on a ventilator. They were also discharged from the hospital sooner. Ibuprofen had no significant adverse effects on the kidneys, gastrointestinal tract or liver.

Health aspects, Evaluation, Prevention, Infants (Premature), Premature infants, Patent ductus arteriosus

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An assessment of the safety of pediatric ibuprofen: a practitioner-based randomized clinical trial

Article Abstract:

Short-term use of ibuprofen in feverish children does not appear to significantly increase the risk of hospitalization for gastrointestinal bleeding, kidney failure, or anaphylaxis. Researchers followed 83,915 children who took fever-reducing medications. Of these, approximately one-third took 12 milligrams of acetaminophen per kilogram of body weight (mg/kg) and two-thirds took ibuprofen in five mg/kg or 10 mg/kg doses. At the four-week follow-up, four children had been hospitalized for treatment of gastrointestinal bleeding. All of these children had taken ibuprofen. The risk of gastrointestinal bleeding was 7.2 cases per 100,000 ibuprofen-treated children and no cases per 100,000 acetaminophen-treated children. No children were hospitalized for anaphylaxis, acute kidney failure, or Reye's syndrome.

Complications and side effects, Risk factors, Gastrointestinal bleeding, Gastrointestinal hemorrhage, Pediatric diseases, Drug therapy, Fever in children, Childhood fever, Anaphylaxis, Acute kidney failure, Acute renal failure in children

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Changes in Sleep Position During infancy

Article Abstract:

Many mothers continue to place their infants on their stomachs to sleep even though this has been shown to increase the risk of sudden infant death syndrome. Researchers surveyed 7,796 mothers of newborn infants. Between 1 month and 3 months of age, the percentage of infants sleeping on their stomachs increased from 18% to 29%. Mothers were more likely to place their infants on their stomach if the mother was black or Hispanic, young, had little education and had more than one child.

Surveys, Infants, Sleep, Sleep positions

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