Effect of Mechanical Ventilation on Inflammatory Mediators in Patients With Acute Respiratory Distress Syndrome: A Randomized Controlled Trial
Article Abstract:
Strategies for protecting the lung during mechanical ventilation may prevent some of the complications of mechanical ventilation. Researchers randomly assigned 44 patients with acute respiratory distress to receive protective strategies or no protective strategies while they were on a ventilator. The protective strategy consisted mainly of preventing overextension of the lungs during ventilation. This was done by basing the amount of ventilation on a volume-pressure curve. Patients who received this protective strategy had lower levels of inflammation in their lung as determined by analysis of bronchoalveolar lavage specimens.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 1999
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Injurious mechanical ventilation and end-organ epithelial cell apoptosis and organ dysfunction in an experimental model of acute respiratory distress syndrome
Article Abstract:
Mechanical ventilators can cause the body to release substances that kill cells, leading to organ malfunction and even death. This could explain why patients with acute respiratory distress syndrome who are placed on a ventilator often die from multiple organ dysfunction rather than from the lung disorder. A study of animals and humans shows that a substance called Fas ligand may be responsible for the damage to other organs.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 2003
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Ventilation strategy using low tidal volumes, recruitment maneuvers, and high positive end-expiratory pressure for acute lung injury and acute respiratory distress syndrome: a randomized controlled trial
Article Abstract:
The effect of a "lung open ventilation" (LOV) strategy on mortality in patients with acute lung injury and acute respiratory distress syndrome is described. A combination of low tidal volumes, recruitment maneuvers, and high levels of positive end-expiratory pressure shows no significant difference in all-cause hospital mortality compared with low-tidal-volume protocolized ventilation strategy.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 2008
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