Effect of omeprazole and ranitidine on ulcer healing and relapse rates in patients with benign gastric ulcer

Article Abstract:

Controlling the secretion of hydrochloric acid (HCL) allows time for gastric ulcers to heal. Omeprazole and ranitidine, drugs which stop the formation of HCL by blocking certain enzymes, were compared with respect to healing rates and symptomatic relief. A double-blind study was conducted at 45 centers in 13 countries of 602 patients with benign gastric or prepyloric ulcers. After 4 weeks of use, healing occurred in 69 percent of the patients receiving omeprazole 20 mg once a day, in 80 percent receiving omeprazole 40 mg once a day and in 59 percent of patients taking ranitidine 150 mg twice a day. The healing rates of omeprazole continued to increase after eight weeks of use and more patients were symptom free after six months. The study shows omeprazole to heal faster and prevent recurrence better than ranititdine at the dosages used.

Ranitidine

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A comparison of omeprazole and placebo for bleeding peptic ulcer

Article Abstract:

Patients with a bleeding peptic ulcer may benefit from the drug omeprazole. Omeprazole is an anti-ulcer drug belonging to a class of drugs called proton pump inhibitors. Researchers randomly allocated 220 patients with bleeding peptic ulcers to take either omeprazole or placebo. After five days, 10.9% of the omeprazole group continued to bleed, compared to 36.4% of the placebo group. About three times as many patients in the placebo group required surgery to stop the bleeding compared to the omeprazole group. One-third of the omeprazole group required a blood transfusion compared to 71% of the placebo group.

Gastrointestinal bleeding, Gastrointestinal hemorrhage

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Percutaneous drainage compared with surgery for hepatic hydatid cysts

Article Abstract:

Draining liver cysts caused by the tapeworm Echinococcus appears to be just as effective as surgery and significantly reduces the patient's hospital stay. Researchers randomly assigned 50 patients with liver cysts to be treated surgically or with drainage supplemented with the anti-parasitic drug albendazole. The average hospital stay in the drainage group was reduced by more than half compared to the surgery group and they were also much less likely to have a complication from the treatment. Drainage was equally effective as surgery in reducing the size of the cyst as well as blood levels of the tapeworm.

Care and treatment, Drainage, Surgical, Drainage (Surgical), Parasitic diseases, Albendazole, Echinococcosis

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