Effects of HIV-1 Tat on expression of HLA class I molecules
Article Abstract:
The HIV-1 Tat protein may not necessarily decrease levels of major histocompatibility complex (MHC) class I proteins. MHC class I proteins are responsible for the recognition and destruction of virally infected cells by the immune system's cytotoxic T lymphocytes. Researchers examined the effect of the presence of Tat proteins in a cell line derived from human immune cells. They observed no changes in MHC class I gene activity or in the presence and processing of HLA-A2 MHC class I proteins. Tat protein, a known gene activator, is crucial in the HIV-1 life cycle and has been reported to have immunosuppressive effects. Decrease in MHC class I gene activity caused by the Tat protein has been proposed to result in the immune dysfunction characteristic of AIDS.
Publication Name: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Subject: Health
ISSN: 1077-9450
Year: 1996
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Dendritic cells transduced with HIV Nef express normal levels of HLA-A and HLA-\b class I molecules
Article Abstract:
The HIV Nef protein does not change HLA class I molecules on the surface of dendritic cells as it does when it infects T cells. Dendritic cells are produced by the immune system.
Publication Name: Journal of Acquired Immune Deficiency Syndromes (1999)
Subject: Health
ISSN: 1525-4135
Year: 2001
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Anti-V3 and anti-IgG antibodies of healthy individuals share complimentarity structures
Article Abstract:
The authors note that certain antibodies which interreact with HIV are also present in people who are HIV-negative. They describe their analyses of structure and type.
Publication Name: Journal of Acquired Immune Deficiency Syndromes (1999)
Subject: Health
ISSN: 1525-4135
Year: 1999
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