Effects of HIV-1 on the surface expression of LFA-1 on cultured monocytes
Article Abstract:
The production of a protein chain called CD11a appears to be affected by HIV infection but is independent of a replication process called reverse transcription. CD11a is part of a receptor molecule on blood cells called LFA-1 that facilitates cell adhesion. CD11a production was monitored in white blood cells infected with a form of HIV or placebo. Cells were then treated with either zidovudine to arrest reverse transcription or placebo. CD11a production was significantly higher in cells infected with HIV compared to placebo. Zidovudine did not have a significant effect on CD11a production.
Publication Name: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Subject: Health
ISSN: 1077-9450
Year: 1997
User Contributions:
Comment about this article or add new information about this topic:
Enhancement of monocyte migration and phagocytosis by the bovine immunodeficiency-like virus Gag proteins
Article Abstract:
Components of the Gag protein of bovine immunodeficiency-like virus (BIV) seem to be capable of stimulating monocyte migration and function. The Gag protein occurs inside the virus but may be released during the breakdown of the virus or the cell it infects. The Gag protein itself is cleaved into smaller fragments. Experiments on a BIV strain isolated from cattle showed that the Gag protein enhanced monocyte migration and function. A fragment of the Gag protein called the p26 capsid appears to be the active component.
Publication Name: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Subject: Health
ISSN: 1077-9450
Year: 1997
User Contributions:
Comment about this article or add new information about this topic:
Adoptive immunotherapy of feline leukemia virus infection using autologous lymph node lymphocytes
Article Abstract:
It may be possible to stimulate immunologically active responses by self-generated transfusions of lymph node lymphocytes. In a test on feline leukemia virus, 16 cats had lymph node cells withdrawn. The cells were cultured with interleukin II for seven days and expanded, then returned intravenously. Antiviral activity took place in 10 of the cats, and nine had improvements that lasted up to 13 months. There is no other established therapy for feline leukemia virus.
Publication Name: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Subject: Health
ISSN: 1077-9450
Year: 1998
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Effect of antibody to HIV-1 Tat protein on viral replication in vitro and progression of HIV-1 disease in vivo
- Abstracts: Getting tough on safety. BSE: existing guidance and future plans
- Abstracts: Protein restriction and progression of chronic renal failure. Diagnosis of food hypersensitivity
- Abstracts: Beyond the stages of sleep: an emerging nursing model of sleep phases. Neonatal sleep patterns: implications for nursing
- Abstracts: The impact of using pharmacy window space for health promotion about emergency contraception. The European Network of Health Promoting Schools: introduction - the UK project