Efficacy of pamidronate in reducing skeletal events in patients with advanced multiple myeloma
Article Abstract:
Pamidronate infusions may help reduce skeletal complications in patients with advanced multiple myeloma, a cancer of the bone marrow. The cancerous cells destroy bone tissue, a cause of fractures, pain, and deformities. Researchers measured the benefits of 90 milligrams of infused pamidronate disodium, an inhibitor of bone resorption, among 196 patients with multiple myeloma. A controlgroup of 181 patients received placebo infusions. After nine months, fewer skeletal complications and less bone pain distinguished the patients who were receiving pamidronate compared to the control group. In addition, fractures occurred later and less frequently, the quality of life improved, and the infusions were well tolerated in the pamidrone group. Two patients discontinued pamidronate therapy due to toxic side effects.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 1996
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A prospective, randomized trial of autologous bone marrow transplantation and chemotherapy in multiple myeloma
Article Abstract:
Treatment with high doses of melphalan combined with bone marrow transplantation may improve response rates and survival rates in patients with myeloma. A total of 200 myeloma patients were randomly allocated to receive conventional chemotherapy or high-dose chemotherapy followed by bone marrow transplant. More patients in the chemotherapy/transplant group achieved complete or very good partial responses compared to those in the conventional chemotherapy group. Survival rates were significantly higher in those who achieved a complete or very good partial response.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 1996
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Lenalidomide plus dexamethasone for relapsed or refractory multiple myeloma
Article Abstract:
The efficacy for lenalidomide plus dexamethasone in the treatment of relapsed or refractory multiple myeloma is determined. Lenalidomide plus dexamethasone is found to be better than high-dose dexamethasone alone.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2007
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