Elevated second-trimester amniotic fluid concentration of insulin-like growth factor binding protein-1 in fetal growth retardation

Article Abstract:

Higher than normal levels of insulin-like growth factor binding protein-1 (IGFBP-1) measured during the second trimester of pregnancy indicate fetal growth retardation. Ultrasonography is the usual method for detecting fetal growth retardation, but this is only effective later in a pregnancy. Amniotic fluid from 148 Finnish women was analyzed to measure concentrations of IGFBP-1 during the 15th and 16th weeks of pregnancy. Blood samples also were taken from 129 of the women. The child's weight and the mother's health status were evaluated by questionnaire. The mothers of small-for-gestational-age children (SGA) had mean amniotic IGFBP-1 levels of 40.5 milligrams per liter (mg/L), but in the non-SGA group the mean was 27.4 mg/L. Mothers of children classified as very SGA had concentrations of 49.4 mg/L. However, measuring IGFBP-1 levels identified only 40% of all SGA infants and 55% of all very SGA infants. No significant differences were found in the levels of IGFBP-1 in the mothers' blood samples.

Measurement, Insulin-like growth factor 1, Insulin-like growth factor I

---

Confined placental mosaicism and intrauterine growth retardation: a case-control analysis of placenta at delivery

Article Abstract:

Chromosomal abnormalities in the placenta of a genetically normal fetus appears to correlate with intrauterine growth retardation (IUGR) of unknown origin. Tissue samples were taken from placental villi and fetal membranes of 12 infants who weighed less than the tenth percentile for gestational age and compared with samples from the placenta and membranes of 24 normal-weight newborns. Samples were cultured and underwent genetic analysis. Microscope slides were prepared from areas away from the sampling site. No cause was known for any of the cases of IUGR. Genetic analysis found that 25% of the IUGR infants had an abnormal number of chromosomes compared with 8% of normal-weight infants. Studies of the microscope slides indicated that the proportion of chromosomally abnormal cells was much higher in the IUGR population than among the normal-weight infants.

Physiological aspects, Genetic aspects, Placenta, Mosaicism

---

Amniotic fluid composition in the fetal lamb with intrauterine growth restriction

Article Abstract:

The osmolality of amniotic fluid does not decrease in fetuses with growth restriction caused by low oxygen levels. Normally, amniotic fluid osmolality does decrease, so this could be a marker for babies who are at risk of a poor birth outcome.

Analysis, Amniotic fluid

Similar abstracts:

• Abstracts: Relief of pruritus and decreases in plasma histamine concentrations during erythropoietin therapy in patients with uremia
• Abstracts: Assessment of fetal activity and amniotic blood fluid volume in the prediction of intrauterine infection in prelabor amniorrhexis
• Abstracts: Reported complications of silicone gel breast implants: an epidemiologic review. Cosmetic surgical procedures and connective tissue disease: the Cleopatra syndrome revisited
• Abstracts: Standardized reporting of clinical practice guidelines: a proposal from the Conference on Guideline Standardization
• Abstracts: Small intestinal bacterial overgrowth in patients with rheumatoid arthritis. Cellular immunity to cartilage aggrecan core protein in patients with rheumatoid arthritis and non-arthritic controls

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.