Endocrine and paracrine control of oocyte development
Article Abstract:
Oocyte development and function may be determined by local (paracrine) and extraovarian (endocrine) factors. The main endocrine hormones regulating oocyte development may be the gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Elevated levels of LH may have an adverse effect on oocyte development, whereas gonadotropins may spur oocyte development. Growth factors secreted by granulosa cells, steroids, cytokines, oocyte maturation inhibitor (OMI), inhibins and activins may all influence the action of gonadotropin on oocytes. Oocyte quality may improve and lead to maturation in women who have gonadotropin deficiencies when LH is absent. Gonadotropin releasing hormone antagonists and recombinant gonadotropins may allow for better control of endocrine, paracrine, and autocrine regulation of follicle growth and oocyte development.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 1995
User Contributions:
Comment about this article or add new information about this topic:
Ovarian control of follicle development
Article Abstract:
The ovary may control follicle growth, selection, and dominance by regulating the secretion of follicle-stimulating hormone (FSH), which in turn may largely control the production of a dominant follicle for ovulation. Growth factors, including insulin-like growth factor-related proteins, may control FSH action. Pituitary gonadotropins may regulate growth factors. The use of gonadotropin releasing hormone (GnRH) antagonists to control pituitary gonadotropin secretion and recombinant FSH and luteinizing hormone to stimulate follicle development may enable manipulation of ovarian steroids and the examination of how steroids influence follicle growth, resorption, and oocyte function in humans. High concentrations of FSH may stimulate the production of intrinsic growth factors by granulosa cells.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 1995
User Contributions:
Comment about this article or add new information about this topic:
Patterns of luteinizing and follicle-stimulating hormone pulsatility in menopausal women: correlation with plasma testosterone level and vasomotor instability episodes
Article Abstract:
Some women who have gone through menopause may be more susceptible to debilitating hot flushes than others. Researchers studied 12 postmenopausal women who were not being treated with estrogen by measuring the levels of various hormones in the blood continuously over a three-hour period. The measurements showed that the women fell into one of two groups. The first group had fewer pulses of luteinizing hormone during the three hours but higher levels of the hormone and experienced fewer instances of debilitating hot flushes. These women were found to have higher levels of testosterone in their blood. The second group of women had more pulses of luteinizing hormone at lower levels, and they experienced more debilitating hot flushes.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 1995
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: A prospective two-year study of progestin given alone in postmenopausal women: effect on lipid and metabolic parameters
- Abstracts: Frequency and effect of adjuvant radiation therapy among women with stage I endometrial adenocarcinoma. Fluorouracil vs gemcitabine chemotherapy before and after fluorouracil-based chemoradiation following resection of pancreatic adenocarcinoma: a randomized controlled trial
- Abstracts: Genomics and malaria control. COL4A1 mutations and hereditary angiopathy, nephropathy, aneurysms, and muscle cramps
- Abstracts: Health system reform in the Republic of China: formulating policy in a market-based health system. The Australian health care system: are the incentives Down Under right side up?
- Abstracts: Cytokine-induced secretion of monocyte chemotactic protein-1 by human endometriotic cells in culture. Expression of dioxin-related transactivating factors and target genes in human eutopic endometrial and endometriotic tissues