Epoprostenol for primary pulmonary hypertension
Article Abstract:
Intravenous epoprostenol (Flolan) may prolong survival and allow for a semblance of normal life in patients with primary pulmonary hypertension (PPH), a rare life-threatening disease characterized by high pressure in the lungs. Epoprostenol rapidly dilates the blood vessels in the lungs and elsewhere. In clinical trials, patients receiving epoprostenol had better exercise capacity, reduced symptoms, and no deaths compared to patients receiving conventional therapy. Three-year survival among PPH patients during epoprostenol administration was higher than among patients not receiving the intravenous drug. Some patients have returned to school and work while taking infusions for years. The cost of the drug and paraphernalia may total over $55,000 per year. Major side effects include nausea, vomiting, hypotension, heart rate abnormalities, chest pain, and shortness of breath.
Publication Name: Medical Letter on Drugs and Therapeutics
Subject: Health
ISSN: 0025-732X
Year: 1996
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Hypertension with a grain of salt
Article Abstract:
Molecular genetic studies have identified multiple genes that cause Mendelian forms of salt-sensitive hypertension or hypotension. Experiments have proved that excessive salt intake contributes to high blood pressure and whether very low-salt diet reduces the blood pressure is still under observation.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2004
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