Exogenous reinfection with multidrug-resistant Mycobacterium tuberculosis in patients with advanced HIV infection

Article Abstract:

Multidrug-resistant tuberculosis appears to result from infection with organisms that are already drug-resistant and from infection with initially drug-sensitive strains that acquire drug resistance. Reports of multidrug-resistant tuberculosis, especially in HIV patients, have been increasing. Using DNA fingerprinting, isolated strains of Mycobacterium tuberculosis from 17 patients were analyzed. All 17 patients tested positive for M. tuberculosis for more than a year. In six of the patients, the strains acquired drug resistance. Four of the patients however, developed multidrug-resistant tuberculosis when reinfected with another strain following successful eradication of the original strain. These findings indicate that reexposure to M. tuberculosis, even among patients with cured tuberculosis, may result in reinfection if the patient fails to acquire protective immunity.

Causes of, Complications and side effects, HIV infection, HIV infections, Drug resistance in microorganisms, Microbial drug resistance

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The evolving relation between humans and Mycobacterium tuberculosis

Article Abstract:

Tuberculosis kills more people around the world than any other infectious disease, yet 90% of all people infected by Mycobacterium tuberculosis never get sick. Environmental factors, characteristics of strains of the bacterium, and differences in human susceptibility may profoundly influence the spread of this disease. Rapid identification and treatment of infected persons, and a better understanding of the many factors which affect transmission, are important components of tuberculosis control.

Editorial, Analysis, Demographic aspects, Disease susceptibility

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Management of tuberculosis in the United States

Article Abstract:

The prevention and treatment of tuberculosis in the US is reviewed. Topics include epidemiology, recommended anti-tuberculosis drugs, HIV patients, tuberculosis in other parts of the body, drug-resistance, tuberculin skin tests and their interpretation.

United States, Care and treatment

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