Famotidine for the prevention of gastric and duodenal ulcers caused by nonsteroidal antiinflammatory drugs

Article Abstract:

High-dose famotidine may be effective in preventing ulcers in people who take nonsteroidal anti-inflammatory drugs (NSAIDS) on a regular basis. Of 248 people who were taking NSAIDS for chronic arthritis, 84 took 20 milligrams (mg) of famotidine twice a day, 83 took 40 mg twice a day and 81 took a placebo. All participants had endoscopy at 4, 12 and 24 weeks to detect the presence of ulcers. The incidence of ulcers was lower in the people taking either dosage of famotidine compared to those taking a placebo. The low dose reduced the incidence of ulcers in the duodenum only while the high dose reduced the incidence of ulcers in both the stomach and duodenum. Those who had erosions and hemorrhages in the lining of the stomach and duodenum were more likely to develop ulcers. Those who were infected with Helicobacter pylori were also more likely to develop ulcers. Side effects attributed to famotidine included abdominal pain, diarrhea and rash.

Evaluation, Prevention, Stomach ulcer, Duodenal ulcer, Famotidine

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Gastrointestinal damage associated with the use of nonsteroidal antiinflammatory drugs

Article Abstract:

Long-term treatment with nonsteroidal anti-inflammatory drugs (NSAID) may cause ulcers of the jejunum or ileum, or the lower portions of the small intestine. Treatment with NSAIDs has been associated with ulcers of the stomach and the duodenum, or the upper portion of the small intestine. Among 713 patients on whom autopsies were performed, 249 had been treated with NSAID during the six months before their death and 464 had not. Twenty-one patients (8.4%) treated with NSAIDs had ulcers of the lower portions of the small intestine, compared with three patients (0.6%) who had not. Fifty-four patients (21.7%) treated with NSAIDs had ulcers of the stomach and duodenum, compared with 57 (12.3%) who had not. Among the 74 patients who had long-term treatment with NSAIDs before their death, three died from complications of ulcers of the jejunum or ileum.

Anti-inflammatory drugs, Anti-inflammatory agents, Intestine, Small, Small intestine

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Gastrointestinal toxicity of nonsteroidal antiinflammatory drugs

Article Abstract:

Pharmaceutical companies continue to search for non-steroidal anti-inflammatory drugs (NSAIDs) that do not damage the gastrointestinal tract. In many people, NSAID damage is minimal and self-healing but many others develop peptic ulcer, small bowel ulcers, diverticulitis and inflammatory bowel disease. Many NSAID-induced gastrointestinal symptoms can be treated with anti-ulcer drugs called H2-receptor antagonist and proton pump inhibitors. If an ulcer develops, the drug should be discontinued. A drug called misoprostol can prevent the recurrence of ulcers.

Causes of, Gastrointestinal diseases, Peptic ulcer

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