Fertility in men exposed prenatally to diethylstilbestrol

Article Abstract:

Prenatal exposure to diethylstilbestrol does not appear to affect a man's fertility. Researchers contacted 494 men between the ages of 38 and 41 whose mothers had taken part in a randomized trial of diethylstilbestrol to treat pregnancy complications between 1950 and 1952. A total of 253 men had been exposed to the drug prenatally during the study and 241 had not been exposed. Fifteen percent of those exposed to the drug had a testicular malformation, compared to 5% of those who were not exposed. However, the incidence of infertility was no higher in those exposed than in those not exposed. Men with testicular malformations were no more likely to be infertile than those without such malformations. The rates of pregnancy in the men's female partners were also similar in the two groups.

Analysis, Fertility, Human, Human fertility, Prenatal influences, Reproductive organs, Male, Male genitalia

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Onset of menopause in women exposed to diethylstilbesterol in utero

Article Abstract:

Women whose mothers took diethylstilbestrol (DES) during their pregnancy do not appear to be at higher risk for early menopause. Telephone interviews were conducted with 542 daughters of mothers who participated in a randomized trial of DES carried out at Chicago Lying-In Hospital from 1950 to 1952. In this group, 296 women were exposed to DES in utero and 246 women's mothers took a placebo. Women were aged 37 to 39 at the time of the interview. The prevalence of hot flashes and night sweats, the most common symptoms of menopause, were similar between groups. Two women, one in each group, had a confirmed diagnosis of premature ovarian failure.

Complications and side effects, Risk factors, Menopause

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Age at menarche among diethylstilbestrol granddaughters

Article Abstract:

Granddaughters of women who took diethylstilbestrol (DES) during pregnancy may not experience delays in the age of first menstruation. Researchers followed up a group of women who had been exposed to DES before they had been born, and their 123 daughters who were over 10 years old. The daughters of the women exposed to DES experienced their first menstrual period at about the same age, 12.7 years, as daughters of women who had not been exposed to DES. DES may not change the age of sexual maturity among granddaughters of women who received DES. The influence of DES on other aspects of health is unknown but is being researched.

Menarche

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