Fetal cardiac function and ductus arteriosus during indomethacin and sulindac therapy for threatened preterm labor: a randomized study
Article Abstract:
Sulindac may produce fewer side effects associated with the fetal heart than indomethacin during the prevention of premature labor. Sulindac is similar to indomethacin by inhibiting prostaglandin synthesis, which is associated with the onset of labor. Researchers compared the fetal heart functions of 20 pregnant women after four-day dosing with either sulindac or indomethacin. At 28 to 32 weeks gestation and impending labor, ten women received sulindac while a second group of ten women received indomethacin. Doppler ultrasound imaging revealed delayed temporary constrictions of the fetal ductus arteriosus, the blood vessel connected to the aorta, among sulindac patients. In contrast, indomethacin produced steadily decreasing heart pulsatility indexes four hours after the start of medication. The right heart ventricle function was affected as well. Heart functions normalized one day after medication with indomethacin ended.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 1995
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Suboptimal neurodevelopment in very preterm infants is related to fetal cardiovascular compromise in placental insufficiency
Article Abstract:
The relationship between fetal cardiovascular hemodynamics and neurodevelopmental outcome in infants born before 32 gestational weeks with placental insufficiency is examined. The decline in fetal weight-indexed cardiac output and the increase in systemic venous pressure were associated with suboptimal neurodevelopment in placental insufficiency with delivery before 32 gestational weeks.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 2005
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Association of severe placental insufficiency and systemic venous pressure risk in the fetus with increased neonatal cardiac troponin T levels
Article Abstract:
Abnormal placental function may damage the fetal heart, according to a study of 66 newborn babies. This was determined by measuring the amount of troponin T in umbilical cord blood taken immediately after birth. Troponin T is a protein in heart muscle that is released into the bloodstream when the heart is injured.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 2000
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