Muscle-mediated gene therapy
Article Abstract:
Muscle cells may be particularly well adapted for use in gene therapy because they fuse with one another and produce chemicals that may circulate to other tissues in the body. Myoblasts, cells from skeletal muscles, can be isolated, grown in culture with viruses carrying desired genes, and injected into host muscles following incorporation of the viral genes. These injected cells may then express the desired genes that may correct disease conditions. These techniques have been somewhat successful in animal models but not yet successful in clinical trials. Injecting DNA directly into muscle can trigger the production of desired antibodies, thus providing a vehicle for vaccination against diseases. DNA may also be implanted in muscle cells that will prevent deterioration of nerves caused by injury and disease. Genetically altered muscle cells may also be implanted in the heart to stimulate growth of new blood vessels after a heart attack.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 1995
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Gene transfer to hematopoietic cells
Article Abstract:
Researchers are working on ways to introduce genes into immature blood cells called stem cells to correct certain diseases. Stem cells multiply over a hundredfold to produce all the different types of blood cells. Thus a gene could be introduced into a few cells, which would multiply and reproduce the gene. And because the resulting cells are blood cells, the gene could be delivered to any part of the body. Research is proceeding on ways to ensure the survival of these cells and to allow them to compete with existing blood cells.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 1996
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