Glyoxalase 1 and glutathione reductase 1 regulate anxiety in mice
Article Abstract:
A genetic manipulation was performed using lentivirus-mediated gene transfer to determine if glyoxalase 1 and glutathione reductase 1 have a casual role in the genesis of anxiety. It was observed that local overexpression of these genes in the mouse brain resulted in increased anxiety-like behavior, while local inhibition of glyoxalase 1 expression by RNA interference decreased the anxiety-like behavior, suggesting that both of these genes were involved in oxidative stress metabolism, linking the pathway with anxiety-related behavior.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2006
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DNA instability in the brain: Survival of the 'fittest'
Article Abstract:
The rapid expansion of neural stem cells that propels the formation of the nervous system, followed by migration and differentiation into appropriate cell types is investigated. The mutations in genes that regulate DNA repair, genome surveillance and the cell cycle are linked to developmental and progressive neurological diseases.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2005
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Expressing what's on your mind: DNA arrays and the brain
Article Abstract:
Neurobiological questions related to the function of the brain and diseases with reference to parallel genome approaches are presented. The expression levels of thousands of genes at a time can be monitored by High-density DNA arrays.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2004
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