G(sub)13 is an essential mediator of platelet activation in hemostasis and thrombosis

Article Abstract:

Results show that G-protein-alpha(sub)13 mediates the potency of thrombin, thromboxane A(sub)2 and collagen leading to changes in platelet shape and aggregation. Furthermore, G-protein-alpha(sub)13 deficiency in platelets causes severe defect in primary hemostasis but protects against arterial thrombosis.

France, All Other Miscellaneous Chemical Product and Preparation Manufacturing, Chemical preparations, not elsewhere classified, Fatty Acids & Derivatives NEC, Physiological aspects, Thromboxanes, Blood platelets, Thrombosis, Platelet activation, Hemostasis, Blood clot

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[G.sub.12]-[G.sub.13]-LARG-mediated signaling in vascular smooth muscle is required for salt-induced hypertension

Article Abstract:

The article discusses the [G.sub.12]-[G.sub.13]-LARG (leukemia associated Rho guanine nucleotide exchange factor)-mediated signaling observed in vascular smooth muscle. The discussed signaling pathway is found be required for the development of salt-induced hypertension in humans.

Science & research, Health aspects, Hypertension, Risk factors, Leukemia, Salt, Salt (Food), Rh factor

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Absence of pressure overload induced myocardial hypertrophy after conditional inactivation of G(alpha)sub(q)/ G(alpha)sub(11) in cardiomyocytes

Article Abstract:

Research presented concerns how the inactivation of a subset of G proteins in cardiomyocytes can induce myocardial hypertrophy. The G(alpha)sub(q)/ G(alpha)sub(11) pathway is discussed.

Statistical Data Included, Cardiomyopathy, Hypertrophic, Hypertrophic cardiomyopathy, Heart cells

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