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Gut microbes out of control in HIV infection

Article Abstract:

A study provides evidence for the cause of immune activation in chronic HIV infection, which might be the breakdown of the gut mucosal barrier and stimulation of immune cells by microbial products, a process termed microbial translocation. The findings suggest that microbial translocation occurs following damage to the surface of the gut mucosa and induction of mucosal CD[4.sup.plus] T-cell depletion by HIV-1, a main aspect of disease pathogenesis.

Author: Haynes, Barton F.

Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2006

Causes of, Risk factors, HIV infection, HIV infections, Immune system

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Annihilating host defense

Article Abstract:

The author analyzes the study on the host defense against bacterial attack. Results indicate the existence of the unknown defence mechanism used by one of the bacteria to infect humans.

Author: Frank, Michael M.

Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2001

Bacteria, Pathogenic microorganisms

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Subjects list: United States, Physiological aspects

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