The management of thrombosis in the antiphospholipid-antibody syndrome

Article Abstract:

Patients with the antiphospholipid-antibody syndrome may require long-term anticoagulation to prevent blood clots. The formation of blood clots in veins and arteries is common in this syndrome, which is characterized by the presence of antibodies against fats in cell membranes. Researchers divided 147 patients with antiphospholipid-antibody syndrome into six treatment groups: no treatment, treatment with aspirin alone, treatment with the anticoagulant drug warfarin at high or low doses, with or without aspirin. After follow-up ranging from one to 21 years, 101 patients developed a blood clot in a vein or artery. None of the patients taking high-dose warfarin and aspirin developed a blood clot, while recurrent blood clots occurred in all other treatment groups. Patients who stopped taking warfarin had a higher recurrence rate within six months than the patients who were never treated. Warfarin caused bleeding in 29 patients, which was easily controlled in 22.

Complications and side effects, Antiphospholipid syndrome, Thrombosis

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Oral anticoagulant therapy for the prevention of stroke

Article Abstract:

Warfarin is no better than aspirin in preventing a second stroke in stroke patients. About one third of all strokes occur in people who have already had one. For this reason, doctors continue to research new approaches for preventing recurring strokes.

Editorial

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A comparison of warfarin and aspirin for the prevention of recurrent ischemic stroke

Article Abstract:

Warfarin and aspirin appear to be equally effective in preventing a second stroke in stroke patients, according to a study of 2,206 patients. The rate of major hemorrhage or bleeding was also similar for either treatment.

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