Hemodynamic and fluid responses to furosemide infusion in the ovine fetus

Article Abstract:

An infusion of the diuretic furosemide in fetal sheep appears to induce changes in fetal blood pressure, heart rate, and urine flow. Diuretics increase urine excretion and are commonly used during pregnancy for fetal evaluations. Fetal sheep received furosemide infusions of 1, 5 or 10 milligrams (mg) per hour and were compared with fetal sheep that did not receive furosemide. Fetal arterial pressure rose significantly and venous pressure dropped significantly during infusions of 5 and 10 mg per hour. Fetal heart rate increased an average of 8 beats per minute at infusions of 10 mg per hour. Fetal blood volume dropped significantly as furosemide concentration increased. As expected, urine flow was significantly greater in fetal sheep that received furosemide than in those that did not. Concentrations of sodium and chloride were also higher in the urine of fetal sheep that received furosemide. The observed changes in blood and urine flow following the furosemide infusions produced an increase in the volume of amniotic fluid.

Models, Hemodynamics, Urination, Furosemide, Diuresis

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Maternal characteristics and risk of severe neonatal thrombocytopenia and intracranial hemorrhage in pregnancies complicated by autoimmune thrombocytopenia

Article Abstract:

Mothers with an autoimmune disease that decreases platelet counts may not place their infants at substantial risk for platelet disorders. Fifty-five mothers with autoimmune thrombocytopenia and their newborns were studied for risk of thrombocytopenia in the fetus and correlations between that risk and the mothers' health history. One infant was born with bleeding within the head. Eight percent of the infants had very low platelet counts. Infants were at increased risk for low platelet counts if their mothers had had their spleens removed. No other characteristics were associated with increased risk.

Complications and side effects, Risk factors, Autoimmune diseases, Pregnancy, Thrombocytopenia, Fetal diseases, Autoimmune diseases in pregnancy

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Regulation of amniotic fluid volume by intramembranous absorption in sheep: role of passive permeability and vascular endothelial growth factor

Article Abstract:

Research has been conducted on passive intramembranous permeability. The authors have tested the hypothesis that the permeability increases in response to fetal intravascular saline solution infusion, and they suggest that vascular endothelial growth gene expression mediates the intramembranous absorption increase.

United States, Research and Development in the Physical, Engineering, and Life Sciences, Science & research, Research and Testing Services, Animal specialties, not elsewhere classified, Laboratory Animals, All Other Animal Production, Gynecological R&D, Health aspects, Research, Analysis, Usage, Genetic aspects, Gene expression, Placenta, Obstetrics, Endothelial growth factors, Gynecological research

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