Hemodynamic response to tibolone in reproductive and nonreproductive tissues in the sheep

Article Abstract:

The drug tibolone (Livial) increases blood flow in the coronary and uterine arteries, according to a study in sheep. This drug is used in hormone replacement therapy in Europe.

Blood flow, Uterus, Livial (Medication)

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Leptin in the ovine fetus correlates with fetal and placental size

Article Abstract:

Leptin appears to be involved in regulating the growth of the fetus, especially during intrauterine growth restriction. Leptin is a hormone produced by fat cells that regulates body weight and the amount of fat in the body.

Research, Body size, Body weights and measures, Leptin

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Fetal responses to maternal and fetal methamphetamine administration in sheep

Article Abstract:

Exposure to methamphetamine during pregnancy may be harmful to both mother and fetus. Methamphetamine is a recreational stimulant drug that may be taken repeatedly. Researchers studied the effects of methamphetamine during pregnancy by exposing pregnant sheep to the drug. Methamphetamine injected into the ewe reduced fetal oxygen while increasing fetal blood pressure. Blood flow in the uterus dropped, while umbilical blood flow increased. When the drug was injected into the fetus, blood pressure and umbilical flow rose significantly, and low fetal pH indicated a severe lack of oxygen. The sheep model of the effects of methamphetamine during pregnancy may supply information that is lacking on the drug's effects in human pregnancies.

Pregnancy, Methamphetamine

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