High-dose chemotherapy for breast cancer
Article Abstract:
More and more physicians and patients are choosing high-dose chemotherapy followed by bone marrow transplant as treatment for breast cancer, but research has not yet established its efficacy nor whether it improves outcomes compared with standard chemotherapy regimes. The theoretical basis for high-dose chemotherapy is sound, and small nonrandomized trials have suggested that it improves outcomes. However, small, nonrandomized trials with limited follow up cannot provide definitive answers. Unfortunately, patient and physician belief in the value of this therapy is making it difficult to recruit patients into the large randomized trial that can provide those answers.
Publication Name: Annals of Internal Medicine
Subject: Health
ISSN: 0003-4819
Year: 1996
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Cancer prevention: better late than never?
Article Abstract:
Many studies done since the 1970's have shown that some cancers can still be prevented even in their late stages. Prior to this, most scientists believed that it took decades for an initial exposure to a carcinogen to develop into cancer. However, many studies have shown that the risk of cancer in middle-aged people can be substantially reduced by eliminating certain risk factors. A 1998 study found that postmenopausal women who used hormone therapy could lower their risk of colorectal cancer. This indicates that preventive efforts close in time to the development of cancer can prevent that step from occurring.
Publication Name: Annals of Internal Medicine
Subject: Health
ISSN: 0003-4819
Year: 1998
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Antimicrobial chemotherapy for Legionnaires disease: time for a change
Article Abstract:
Physicians should consider using some of the newer fluoroquinolone antibiotics to treat Legionnaire's disease. The usual treatment is erythromycin, and this is probably sufficient for most healthy patients who have healthy immune systems. However, erythromycin is less effective in hospital patients who may have other medical conditions in addition to Legionnaire's disease. Erythromycin also has serious side effects. Fluoroquinolones such as ciprofloxacin, levofloxacin, trovafloxacin, sparfloxacin and perfloxacin are most effective against Legionella in laboratory research.
Publication Name: Annals of Internal Medicine
Subject: Health
ISSN: 0003-4819
Year: 1998
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