High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin
Article Abstract:
Erythroblast transcriptome profiles from healthy, nonthalassemic donors are examined in order to test if the accumulation of iron in the absence of blood transfusions might result from inappropriate suppression of the iron-regulating peptide hepcidin. The results have shown that the growth differentiation factor 15 (GDF15) overexpression arising from an expanded erythroid compartment has contributed to iron overload in thalassemia syndromes by inhibiting hepcidin expression.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2007
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Progress and potential for regenerative medicine
Article Abstract:
Regenerative medicine focuses on new therapies aimed to replace or restore lost, damaged, or aging cells in the human body to restore function and hence collaborative efforts are on in nonmammalian and human development, genetics, and tissue engineering. The development in limb regeneration, fetal wound healing, stem cell biology, and tissue engineering as a foundation for developing new clinical therapies to enhance and stimulate human regeneration, is reviewed.
Publication Name: Annual Review of Medicine
Subject: Health
ISSN: 0066-4219
Year: 2007
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