Airway epithelial gene expression in the diagnostic evaluation of smokers with suspect lung cancer
Article Abstract:
Affymetrix HG-U133A microarrays are used to perform gene-expression profiling of large-airway epithelian cell brushings obtained from current and former smokers who underwent flexible bronchoscopy, as a diagnostic study of clinical suspicion of lung cancer. The results have shown that gene expression in cytologically normal large-airway epithelial cells can serve as a lung cancer biomarker, owing to a cancer-specific airway-wide response to cigarette smoke.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2007
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Staphylococcus aureus protein A induces airway epithelial inflammatory responses by activating TNFR1
Article Abstract:
A study was conducted to examine the interactions of Staphylococcus aureus protein A and airway epithelial cells. The result shows that protein A has a chief role in the induction of pneumonia and the recruitment of polymorphonuclear leukocytes (PMNs) into the airway through activation of TNFR1, a receptor for tumor-necrosis factor-alpha (TNF-alpha).
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2004
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A GABAergic system in airway epithelium is essential for mucus overproduction in asthma
Article Abstract:
The role of airway epithelial cells in the production of mucus due to allergic reactions in asthma was studied and options for asthma management presented.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2007
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