Human cardiovascular and metabolic response to acute, severe isovolemic anemia
Article Abstract:
Healthy adults may tolerate extreme acute anemia without decreased oxygen delivery or evidence of heart injury. Researchers examined the effects of anemia in 32 resting volunteers by removing blood and maintaining normal blood volume with plasma or albumin. Anemia produced an increase in heart rate and blood flow, which maintained oxygen delivery at hemoglobin levels of 50 grams per liter. Most study volunteers showed no changes in heart rhythm indicative of inadequate blood supply. Such extreme anemia may be tolerable in some healthy surgery patients who have no heart or vessel disease.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 1998
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Research Opportunities in Transfusion Medicine
Article Abstract:
Efforts must be made to increase blood donations and to ensure the safety of the US blood supply. In addition, it may be possible to grow progenitor cells for replacing defective cells that are causing disease. Stem cells are one such type of cell that can produce many different cell types. These cells can also be genetically modified to correct genetic disorders.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 2001
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Gene and Stem Cell Therapies
Article Abstract:
The discovery of the stem cell may revolutionize the treatment of many diseases. Stem cells are embryonic cells that can differentiate into many different types of cells. Gene therapy can be used to replace defective genes but doctors must develop a device for delivering the gene to the tissues that need it.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 2001
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