Hyaluronan accumulates in demyelinated lesions and inhibits oligodendrocyte progenitor maturation

Article Abstract:

A demonstration that the glycosaminoglycan hyaluronan accumulates in remyelinated lesions from individuals with multiple sclerosis and in mice with experimental autoimmune encephalomyelitis is presented. A high molecular weight (HMW) form of hyaluronan synthesized by astrocytes accumulates in chronic demyelinated lesions and this form of hyaluronan inhibits remeylination after lysolecithin-induced white matter demyelination.

Diagnosis, Multiple sclerosis, Glycosaminoglycans, Mucopolysaccharides

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Regulation of lung injury and repair by Toll-like receptors and hyaluronan

Article Abstract:

A report that hyaluronan degradation products require MyD88 and both toll=-like receptor (TLR)4 and TLR2 in vitro and vivo to initiate inflammatory responses in acute lung injury is presented. Hyaluronan-TLR2 and hyaluronan-TLR4 interactions provide signals that initiate inflammatory responses, maintain epithelial cell integrity and promote recovery from acute lung injury.

Care and treatment, Cell receptors, Acute respiratory distress syndrome, Adult respiratory distress syndrome

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Uptake of HIV-1 Tat protein mediated by low-density lipoprotein receptor-related protein disrupts the neuronal metabolic balance of the receptor ligands

Article Abstract:

Research suggests that HIV-1 transactivator (Tat) protein may act as a mediator for HIV-1-induced neuropathology by binding to low-density lipoprotein receptor-related proteins (LRP), thereby disrupting LRP ligand metabolic balance. This process also significantly inhibits neuronal binding, uptake and degradation of LRP physiological ligands.

Statistical Data Included, Physiological aspects, Proteins, Ligands (Biochemistry), Low density lipoproteins, Anti-HIV agents

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