Hyaluronate in rheumatology and orthopaedics: Is there a role?
Article Abstract:
Preliminary findings that injection of hyaluronate, or hyaluronic acid, into the arthritic joints improves joint function have led to the idea that hyaluronate may become therapeutically useful. Hyaluronate is composed of sugar molecules, which can be strung together in various lengths, forming a complex carbohydrate that increases the viscosity of fluids. Hyaluronate is the major macromolecular (consisting of a large molecule, such as proteins) component of synovial fluid, which surrounds and lubricates joint surfaces, and it is also found within the cartilage that makes up the joint surfaces. In rheumatoid arthritis, there is a decrease in the production, amount, and size of hyaluronate. With increasing age, hyaluronate levels can increase five-fold, but these hyaluronates consist of smaller molecules. High molecular weight hyaluronate inhibits cellular proliferation, which may be important in suppressing inflammation in joints. Hyaluronate can decrease joint pain and appears to be anti-inflammatory in cases of moderate arthritis, with possible long-term benefits. However, no improvement in overall function was noted in one study. Notably, no serious side effects are associated with hyaluronate therapy. Proposed uses for hyaluronate include lubrication of joints during joint surgery, and treatment following surgical repair of joints, nerves, and cartilage, and following trauma or tissue removal. Controlled trials of hyaluronate for these uses are needed to determine effectiveness and optimum dosage. (Consumer Summary produced by Reliance Medical Information, Inc.)
Publication Name: Annals of the Rheumatic Diseases
Subject: Health
ISSN: 0003-4967
Year: 1990
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Bridging the gap in rheumatology
Article Abstract:
Doctors discuss the treatment of children and teenagers with juvenile idiopathic arthritis. This form of arthritis is different in many ways from adult arthritis and is compounded by the normal problems of adolescence.
Publication Name: Annals of the Rheumatic Diseases
Subject: Health
ISSN: 0003-4967
Year: 2000
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First clinical evaluation of sagittal laser optical tomography for detection of synovitis in arthritic finger joints
Article Abstract:
The usage of Optical tomography to detect synovitis in arthritic finger joints is examined.
Publication Name: Annals of the Rheumatic Diseases
Subject: Health
ISSN: 0003-4967
Year: 2005
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