Hydroxyurea-induced leg ulceration in 14 patients
Article Abstract:
Hydroxyurea therapy can cause painful leg ulcers that only heal after discontinuation of the drug. Hydroxyurea is an anticancer drug used in the treatment of leukemia, other myeloproliferative disorders, and other conditions. Doctors present 14 cases of severe leg ulcerations in patients taking hydroxyurea for an average of six years. Most ulcers were on the ankle, and failed to respond to aggressive wound management. Discontinuation of hydroxyurea resulted in healing, and reinstitution of the drug in some patients caused the ulcers to recur.
Publication Name: Annals of Internal Medicine
Subject: Health
ISSN: 0003-4819
Year: 1998
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Hydroxyurea-induced leg ulceration in 14 patients
Article Abstract:
The development of painful leg sores may be a common side effect of hydroxyurea treatment for cancer. The medical findings on 14 patients with bone marrow cancers treated with hydroxyurea who developed leg ulcers are described. Ulcers developed most frequently on the ankle, typically years after the start of treatment, and resolved after stopping treatment. Ulcers redeveloped in two patients given hydroxyurea therapy again. Sixty-four percent of the patients had more than one ulcer.
Publication Name: Annals of Internal Medicine
Subject: Health
ISSN: 0003-4819
Year: 1998
User Contributions:
Comment about this article or add new information about this topic:
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