Hypoxia pathway linked to kidney failure
Article Abstract:
Rapidly progressive glomerulonephritis (RPGN) is a life-threatening disease in which affected individuals lose kidney function over a period of days to weeks due to the activation of the oxygen-regulated hypoxia-inducible factor 1 (Hif1) and its target gene Cxcr4 that lead to increased cell proliferation that interferes with the function of the glomerulus. Scientists have succeeded in identifying a mechanism that underlie a form of human kidney failure in knockout mice and have found that treatment of the mice with neutralizing antibodies Cxcr4 to slow disease progression and increased survival.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2006
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Functional and morphological recovery of dystrophic muscles in mice treated with deacetylase inhibitors
Article Abstract:
A study was conducted to show that deacetylase inhibitors increase the size of myofibers in dystrophin-deficient (MDX) and [alpha]-sarcoglycan ([alpha]-SG)-deficient mice by inducing the expression of the myostatin antagonist follistatin in satellite cells. Deacetylase inhibitor treatment conferred on dystrophic muscles resistance to contraction-coupled on dystrophic muscles resistance to contraction-coupled degeneration and alleviated both morphological and functional consequences of the primary genetic defect.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2006
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Setting a trap for tissue fibrosis
Article Abstract:
A kielin/chordinlike protein (KCP) that negatively regulates kidney fibrosis is identified. It is shown that KCP operates by facilitating the action of another cytokine found to protect against fibrosis, the signaling ligand bone morphogenic protein 7 (BMP7).
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2005
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