Immunologic and virologic markers determining progression to AIDS
Article Abstract:
A combination of indicators, including virus types, rates of CD4 cell count decline, and immune cell response, may be useful in predicting and evaluating disease progression in patients with human immunodeficiency virus (HIV). Researchers highlighted recent studies that evaluated the effectiveness of three indicators that predict and evaluate progression to acquired immunodeficiency syndrome (AIDS). There seems to be an association between the presence of a virus type called the syncytium-inducing (SI) variant and disease progression. Of 178 patients positive for HIV, 62% of the patients carrying the SI virus type developed AIDS while only 18% of the patients not carrying the SI virus type developed AIDS. CD4 cell counts in patients that progress to AIDS typically decrease three to five times faster in the months prior to an AIDS diagnosis. Studies also showed that 60% of patients with either low CD4 cell counts or low immune cell reactivity developed AIDS.
Publication Name: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Subject: Health
ISSN: 1077-9450
Year: 1995
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Prognostic value of HIV-1 syncytium-inducing phenotype for rate of CD4+ cell depletion and progression to AIDS
Article Abstract:
Isolation of syncytium-inducing (SI) HIV strains among infected patients appears to predict an increased rate of CD4 T-cell decline. A syncytium is a mass of cells. CD4 T-cells are a type of white blood cell depleted in HIV infection, but the rate of depletion varies from patient to patient. Furthermore, the risk of progression to AIDS varies even among patients with the same CD4 T-cell count. SI strains of HIV were initially detected in 22 of 188 men with early HIV infection. Another 22 men later converted to SI type during the study. Overall, 36 men progressed to AIDS. However, the probability of progression to AIDS was 70.8% among the 22 men who initially had SI isolates compared with 15.8% among men who did not have SI isolates. Of the 22 men who converted to SI during the study, five developed AIDS.
Publication Name: Annals of Internal Medicine
Subject: Health
ISSN: 0003-4819
Year: 1993
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Body mass index course in asymptomatic HIV-infected homosexual men and the predictive value of a decrease of body mass index for progression to AIDS
Article Abstract:
It is possible that measurement of weight changes, especially the decline of body mass during the asymptomatic period of HIV infection can be used as a predictive value to determine progression to AIDS. Weight changes during the asymptomatic period have not, before now, been accurately noted. The progression of changes in body mass index (BMI) was studied in 122 cases of HIV positive individuals. In 56 AIDS cases, a steep decline in BMI was seen in the six months before AIDS became evident. The steeper the decline, the faster conversion to AIDS.
Publication Name: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Subject: Health
ISSN: 1077-9450
Year: 1998
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