Implication of HTLV-I infection, strongyloidiasis, and P53 overexpression in the development, response to treatment, and evolution of non-Hodgkin's lymphomas in an endemic area (Martinique, French West Indies)
Article Abstract:
Several factors can influence the responsiveness of patients with HTLV-I infection to treatment. Researchers analyzed these factors in 41 people with T cell lymphomas. Fifty-nine percent tested positive for HTLV-I, which is a retrovirus. All but five had adult T-cell leukemia/lymphoma (ATLL), which is linked to HTLV-I. Four also tested positive for a parasite called Strongyloides stercoralis, and all responded completely to treatment. Only two of seven ATLL patients who tested negative for this parasite responded to treatment. Elevated blood levels of the p53 protein were associated with resistance to treatment.
Publication Name: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Subject: Health
ISSN: 1077-9450
Year: 1999
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Clonal expansion of infected cells: a way of life for HTLV-I
Article Abstract:
The human T-cell lymphotropic virus type I (HTLV-I) appears to reproduce primarily by mitosis. The virus infects T cells and then causes the cells to proliferate. This would explain the extreme genetic stability of the virus. It could also explain why people can be infected with the virus for years or even decades before developing chronic disease. The virus does not reproduce actively via reverse transcription, like HIV does. This means that it would take a long time for the virus to accumulate genetic mutations that would make it cause leukemia.
Publication Name: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Subject: Health
ISSN: 1077-9450
Year: 1996
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What is the situation of human T cell lymphotropic virus type II (HTLV-II) in Africa? Origin and dissemination of genomic subtypes
Article Abstract:
It appears that human T cell lymphotropic virus type II (HTLV-I) may have originated in Africa. It was formerly thought to occur only in the Americas, where it was presumed to have been brought during the migration from Asia to America over the Bering land bridge. However, it has been found in Africa. HTLV-II and its closely related cousin, HTLV-I, are believed to be descended from viruses that occur in African monkeys. Some of these simian viruses still exist, leading to the possibility that a new human virus may be discovered.
Publication Name: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Subject: Health
ISSN: 1077-9450
Year: 1996
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