In vitro comparison of selected triple-drug combinations for suppression of HIV-1 replication: the inter-company collaboration protocol
Article Abstract:
Early intervention with triple-drug combination therapies that include zidovudine (AZT) may prove effective in treating patients with human immunodeficiency virus (HIV). Researchers analyzed the response of two HIV cell lines to 10 combinations of three-drug therapies each of which included AZT. The other currently available drugs included in the combination tests were dideoxycytosine (ddC), dideoxyinosine (ddI), nevirapine, 3TC, L-735,524, and Ro 31-8959. All 10 of the drug combinations were more effective in reducing cellular HIV disease than any of the drugs used alone or as a double-drug combination. The most effective combination was AZT, ddC, and 3TC. Three of the drug combinations were capable of completely stopping viral reproduction of both cell lines. Treatment was slightly more effective on the HIV-1 3B cell line than the HIV-1 MN cell line. The therapies were less effective with greater concentrations of the viruses.
Publication Name: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Subject: Health
ISSN: 1077-9450
Year: 1995
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Inter-company collaboration combination trials
Article Abstract:
Testing for triple-drug therapies for patients with human immunodeficiency virus (HIV) may soon begin. Researchers from 15 major drug companies have joined forces in proposing two year-long studies of four triple-drug therapies for patients with HIV. One study would compare the effectiveness of combined zidovudine (AZT), zalcitabine (ddC), and either saquinavir or nevirapine with AZT and ddC alone (controls). The second study would compare the effectiveness of combinations of AZT, didanosine (ddI) and either lamivudine or nevirapine with AZT and ddI alone (controls). Physicians would treat 75 HIV-positive patients with each of these treatment combinations. Enrolled patients should not have received any retroviral drug treatment before enrollment in the study and have CD4 cell counts between 200-500. The studies would evaluate the patients' viral concentrations and resistance, CD4 cell counts, and disease progression.
Publication Name: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Subject: Health
ISSN: 1077-9450
Year: 1995
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Rapid screening of antiretroviral combinations
Article Abstract:
In vitro analysis quantifying the antiretroviral properties of major HIV drugs may help in the selection of appropriate combination drug protocols. The procedure is a highly automated cell-protective assay involving infected MT4 cells exposed to various drug combinations versus monotherapy with zidovudine (AZT). The triple combination of AZT/ddI/3TC was most effective in eliminating viral replication, an improvement over both dual drug therapy and monotherapy. Evaluation of the new drug 935U83 yielded best results in the triple combination 935/AZT/3TC, compared to a grouping of 935/ddI/3TC. The drugs AZT and 3TC are thought to work better together than in combination with others. This in vitro procedure can also mimic cell responses in drug resistance, a common problem in patients taking AZT.
Publication Name: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Subject: Health
ISSN: 1077-9450
Year: 1995
User Contributions:
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