Incidence of ovarian failure in systemic lupus erythematosus after treatment with pulse cyclophosphamide

Article Abstract:

It appears that women with systemic lupus erythematosus (SLE) who have taken cyclophosphamide are more likely to experience an early menopause. Researchers interviewed 35 women with SLE who had taken cyclophosphamide (study group), 20 women with SLE who had taken azathioprine (study controls), and 35 healthy female volunteers (healthy controls). They also reviewed the medical records of the study group and study controls. Among the study group patients younger than 40 years, 41% had an early menopause. None of the study controls or healthy controls had an early menopause. Patients treated for longer than six months, those that were older at the start of treatment, and those with low neutrophil counts before treatment were more likely to have an early menopause. Patients taking a higher total amount of cyclophosphamide tended to have an early menopause. Taking oral contraceptives during treatment did not seem to protect against an early menopause.

Complications and side effects, Drug therapy, Menopause, Ovaries, Cyclophosphamide

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Smoking history, alcohol consumption, and systemic lupus erythematosus: a case-control study

Article Abstract:

The risk of developing the autoimmune condition systemic lupus erythematosus (SLE) may be higher in smokers and lower in people who drink alcohol, compared to those who do not drink or use tobacco. Researchers interviewed 150 SLE patients and 300 healthy, similar volunteers to determine the environmental factors that might be associated with the condition. Smokers where almost twice as likely as non-smokers and ex-smokers to have SLE, while drinkers were less likely to have SLE than abstainers.

Health aspects, Risk factors, Drinking of alcoholic beverages, Drinking (Alcoholic beverages), Tobacco habit

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Restrictions of T cell receptor beta chain repertoire in the peripheral blood of patients with systemic lupus erythematosus

Article Abstract:

Active systemic lupus erythematosus (SLE) may be associated with increases in T cells of a limited few subtypes. T cells mediate immune reactions and are involved in the disease process of SLE. Researchers typed T cells from the blood of two healthy women and five SLE patients. Three women with inactive disease showed similar patterns to the healthy women, but two women with active disease showed a marked increase of a few subtypes of T cells.

Physiological aspects, T cell antigen receptors, T cells

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