Increased cell division but not thymic dysfunction rapidly affects the T-cell receptor excision circle content of the naive T cell population in HIV-1 infection
Article Abstract:
In healthy individuals, declining thymic output affects T cell receptor excision circles (TRECs) in conjunction with naive T-cell division whereas in HIV-1 infected individuals, declining TRECs are correlated with the changes in peripheral T-cell division, which does not involve thymic impairment. This suggests a relationship between immune activation and TREC content.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2000
User Contributions:
Comment about this article or add new information about this topic:
The dominant source of CD4+ and CD8+ T-cell activation in HIV infection is antigenic stimulation
Article Abstract:
The persistence of HIV antigens may explain why T cell activation persists in HIV patients even when they take AIDS drugs. This was the conclusion of a study of 47 HIV patients before and after they began drug treatment.
Publication Name: Journal of Acquired Immune Deficiency Syndromes (1999)
Subject: Health
ISSN: 1525-4135
Year: 2000
User Contributions:
Comment about this article or add new information about this topic:
HIV-1 subtype C Gag-specific T-cell responses in relation to human leukocyte antigens in a diverse population of HIV-infected Ethiopians
Article Abstract:
HIV-1 subtype C T-cell responses measured in a diverse population of infected Ethiopian subjects using synthetic Gag peptides is presented as it is a necessary requisite in the development of HIV vaccine.
Publication Name: Journal of Acquired Immune Deficiency Syndromes (1999)
Subject: Health
ISSN: 1525-4135
Year: 2007
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Thymic function after hematopoietic stem-cell transplantation for the treatment of severe combined immunodeficiency
- Abstracts: Effect of reperfusion on biventricular function and survival after right ventricular infarction. Multiple complex coronary plaques in patients with acute myocardial infarction
- Abstracts: Cost and enrollment implications of targeting different source population for an HIV treatment program. Cost-effective use of nevirapine to prevent vertical HIV transmission in sub-Saharan Africa
- Abstracts: Response rates with different distribution methods and reward, and reproducibility of a quantitative food frequency questionnaire
- Abstracts: Design and construction of an experimental HIV-1 vaccine for a year-2000 clinical trial in Kenya. HIV vaccines 1983-2003