Increased expression of integrins on fibroblast-like synoviocytes from rheumatoid arthritis in vitro correlates with enhanced binding to extracellular matrix proteins

Article Abstract:

Synovial tissue cells from patients with rheumatoid arthritis appear to contain more surface receptors called integrins to bind proteins from outside the cells. Synovial tissue cells from patients with rheumatoid arthritis and normal individuals were compared for the presence of integrin subunits and their capacity to bind proteins typically found outside these cells. There were more integrin subunits expressed in the diseased samples including beta 1, beta 4, and alpha 1 through alpha 6. These diseased samples also had an increased capacity to bind proteins compared to the normal samples.

Diagnosis

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Differential expression and functional behaviour of the alpha-v and beta-3 integrin subunits in cytokine stimulated fibroblast-like cells derived from synovial tissue of rheumatoid arthritis and osteoarthritis in vitro

Article Abstract:

Vitronectin receptors in the synovial tissue of joints may play a role in the inflammation and tissue damage in rheumatoid and osteoarthritis. Normal joints have similar distributions of alpha-v and beta-3 integrin subunits of vitronectin receptors, which promote cell adhesion and could be important in healing and tissue remodelling. Osteoarthritic joints have significant alpha-v receptors, while rheumatoid arthritic joints have variable alpha-v receptors. Beta-3 receptors are lacking in both diseases. These receptors may affect synovial and collagen damage in arthritic joints.

Osteoarthritis, Cell receptors

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Methotrexate in patients with moderate systemic lupus erythematosus (exclusion of renal and central nervous system disease)

Article Abstract:

Methotrexate (MTX) seems to be effective in reducing disease activity in patients with systemic lupus erythematosus (SLE), especially those with arthritis. After six months, a group of 19 women and three men with SLE taking MTX experienced a significant decrease in their symptoms. Of those with arthritis, 10 of 12 had complete suppression of their symptoms. Many of the patients were able to reduce their corticosteroid dose.

Drug therapy, Corticosteroids, Adrenocortical hormones, Systemic lupus erythematosus, Methotrexate

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