Induction of endothelial cell tissue factor activity by sera from patients with antiphospholipid syndrome: a possible mechanism of thrombosis
Article Abstract:
Antiphospholipid antibodies may increase the risk of thrombosis by stimulating tissue factor activity. Tissue factor is a specialized protein that initiates blood clot formation when expressed on the surface of the cell membrane. Thrombosis is the formation of a blood clot within a blood vessel and can be fatal. In the laboratory, human umbilical cells were grown in culture and treated either with blood from healthy humans or with blood containing antiphospholipid antibodies. Tissue factor activity was significantly greater in the cultures treated with blood containing antiphospholipid antibodies than in those treated with normal blood. When the cultures were treated with only the gamma immunoglobulin (IgG) from the blood samples, tissue factor activity was even more pronounced in those treated with samples containing antiphospholipid antibodies than in those treated with samples derived from normal blood. This suggests that the ability to induce tissue factor expression is contained at least partially within the IgG.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 1993
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Regulation of expression of tissue plasminogen activator and plasminogen activator inhibitor-1 by dichloroacetic acid in human fibroblasts from normal peritoneum and adhesions
Article Abstract:
Stimulation of aerobic metabolism would alter differential expression of tissue plasminogen activator and plasminogen activator inhibitor-1 creating a milieu likely to be less favorable to postoperative adhesion development. The result reveals that normal peritoneal fibroblasts under hypoxic conditions, and in adhesion fibroblasts under normoxic and hypoxic conditions, dichloroacetic acid greatly increased in the tissue plasminogen activator inhibitor-1.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 2004
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Normal expression of tissue factor, thrombomodulin, and annexin V in placentas from women with antiphospholipid syndrome
Article Abstract:
The placentas of pregnant women with antiphospholipid syndrome have normal levels of thrombomodulin and annexin V. These are both anticoagulants and were thought to be depleted, thus predisposing these women to abnormal blood clotting. This in turn leads to preeclampsia, intrauterine growth restriction and premature birth.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 1999
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