Inflammatory Markers in Coronary Artery Disease: Let Prevention Douse the Flames

Article Abstract:

Increasing evidence points to the role that inflammation plays in coronary artery disease (CAD). However, it may be premature to measure blood levels of inflammatory substances to diagnose CAD or to develop drugs that lower blood levels of these substances to treat CAD. Many CAD patients are not prescribed drugs that are known to be effective, including beta blockers, ACE inhibitors, and anticoagulants.

Physiological aspects, Coronary heart disease, Inflammation, Inflammation mediators

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Prevention of atherosclerosis in coronary-artery bypass grafts

Article Abstract:

Recent studies have shown that aggressive lipid-lowering medication can help prevent or slow the formation of blocked blood vessels in patients who have had bypass surgery. Moderate strengths of lipid-lowering medication did not achieve similar results. Anti-clotting medication has had beneficial effects in native and newly grafted vessels but not past one year following bypass surgery. However, it is still advisable for patients who have had bypass surgery to take aspirin to prevent blockage in native and newly grafted vessels.

Complications and side effects, Transplantation of organs, tissues, etc., Organ transplantation, Tissue transplantation, Transplantation, Coronary artery bypass

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Platelet Glycoprotein IIb/IIIa Receptor Antagonists in Cardiovascular Disease

Article Abstract:

Drugs that block the platelet glycoprotein (GP) IIb/IIIa receptor may prevent heart attack in some patients. Most heart attacks occur when a blood clot forms on atherosclerotic plaque in the coronary arteries. Platelets are one component of a blood clot and the GP IIb/IIIa receptor is how they bind to each other and to other cells. Two classes of drugs that can block this reaction are monoclonal antibodies against the receptor and pieces of the receptor itself. These drugs include abciximab, eptifibatide, tirofiban and lamifiban. They are effective in preventing heart attack in some patients, but must be given intravenously.

Health aspects, Heart attack, Monoclonal antibodies, Blood platelets, Blood clotting, Blood coagulation, Platelet-derived growth factor receptors

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