Inhaled Budesonide in Addition to Oral Corticosteroids to Prevent Asthma Relapse Following Discharge From the Emergency Department: A Randomized Controlled Trial
Article Abstract:
Patients discharged from a hospital emergency room following treatment for acute asthma may benefit from high-dose inhaled budesonide in addition to oral corticosteroids. This was the conclusion of a study of 188 asthma patients discharged from a hospital, half of whom were randomly assigned to take oral corticosteroids alone and half received oral corticosteroids plus inhaled budesonide. Patients taking both drugs were half as likely to have a relapse as those taking only oral drugs. They also had fewer asthma symptoms, a higher quality of life, and were less likely to use beta agonists to control their asthma.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 1999
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Antileukotriene Drugs in the Management of Asthma
Article Abstract:
Antileukotriene drugs may be beneficial in the treatment of asthma. These drugs inhibit leukotrienes, which are naturally occurring chemicals in the body that constrict the lungs and increase mucus production. Oral antileukotriene drugs available for the treatment of asthma include montelukast, zafirlukast, pranlukast, and zileuton. These drugs have an anti-inflammatory effect as well as dilating bronchial passages. They have been shown to reduce asthma symptoms and may also allow patients to take lower doses of inhaled corticosteroids. However, not all patients will respond to antileukotriene drugs.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 1998
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Montelukast for chronic asthma in 6- to 14-year-old children: a randomized, double-blind trial
Article Abstract:
The drug montelukast may be beneficial in young children with asthma. The drug blocks the action of leukotrienes, which cause lung passages to constrict. Researchers gave a chewable tablet containing montelukast or a placebo to 336 6- to 14-year-old children with asthma. The drug improved lung function significantly better than the placebo. A few children developed an adverse reaction to the drug and the most common side effects were headache, upper respiratory tract infection, and asthma.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 1998
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