Inhaled nebulized nitrite is a hypoxia-sensitive NO-dependent selective pulmonary vasodilator
Article Abstract:
The blood anion nitrite contribute to hypoxic vasodilation through a heme-based, nitric oxide (NO) and the biochemical reaction could be harnessed for the treatment of neonatal pulmonary hypertension. An experiment conducted by inhaling sodium nitrite by aerosol to newborn lambs with hypoxic and normoxic hypertension is presented. The results revealed that nitrite is a simple and inexpensive potential therapy for neonatal pulmonary hypertension.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2004
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Nitric oxide's reactions with hemoglobin: a view through the SNO-storm
Article Abstract:
This article evaluates the role of S-nitroso-hemoglobin in the regulation of basal blood flow and tissue oxygenation through allosteric binding and delivery of nitric oxide and oxygen. Research shows that this hypothesis is not tenable but an alternative pathway of nitric oxide scavenging by hemoglobin and nitric oxide production by endothelial cells may be determining nitric oxide bioavailability.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2003
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Hemoglobin and the paracrine and endocrine functions of nitric oxide
Article Abstract:
Nitric oxide is produced by blood vessels and most researchers believe it only acts on surrounding tissues to relax the blood vessel. However, there is some evidence that it can be transported in the blood to other parts of the body. This would make it act more like a hormone. It could also be used as a drug to treat some cardiovascular diseases.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2003
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