Inhibitors of histone deacetylases induce tumor-selective apoptosis through activation of the death receptor way
Article Abstract:
The effects of inhibitors of histone deacetylases (HDACls) on leukemias expressing in PML-RAR or AML1-ETO oncoproteins were investigated. The results show that sensitivity to HDACls in leukemias is a property of the fully transformed phenotype and depends on activation of a specific death pathway.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2005
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Autoimmunity and tumor immunity induced by immune responses to mutations in self
Article Abstract:
Black mice were immunized by using combinatorial DNA libraries encoding large numbers of random mutations in two syngeneic tyrosinase-related proteins. Autoimmune hypopigmentation and tumor immunity were induced through cross-recognition of nonmutated gene products by the libraries of mutated DNA.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2006
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B-cell lymphoma: Suppressing a tumor suppressor
Article Abstract:
Diffused large B-cell lymphoma (DLBCL) is an aggressive cancer that accounts for about 40% of non-Hodgkin lymphomas. Phan and Dalla-Favera provided an insight about the operation of BCL-6, showing that BCL-6 can directly repress the transcription of the p53 tumor suppressor gene.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2005
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