Integration of endoplasmic reticulum signaling in health and disease
Article Abstract:
Integration of endoplasmic reticulum (ER) signaling in health/disease is discussed. Change in the ER processing of cargo molecules by pathogens or inadequacies in cargo handling by the ER mechanisms in a range of diseases from cystic fibrosis to hemochromatosis and neuropathies such as Alzheimer disease shows a surprising role of the ER in cell fate control. Topics include chaperones in assisted folding in the ER and cellular control of ligands regulating ER export.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 1999
User Contributions:
Comment about this article or add new information about this topic:
BMP-2 mediates retinoid-induced apoptosis in medulloblastoma cells through a paracrine effect
Article Abstract:
It is believed that retinoids cause extensive apoptosis of medulloblastoma cells. Bone morphogenetic protein-2 (BMP-2) was identified as a candidate mediator of retinoid activity, which induced medulloblastoma cell apoptosis, whereas the BMP-2 antagonist noggin blocked both retinoid and BMP-2-induced apoptosis.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2003
User Contributions:
Comment about this article or add new information about this topic:
The neuronal repressor REST/NRSF is an essential regulator in medulloblastoma cells
Article Abstract:
Research presented concerns the mechanism responsible for medulloblastoma tumorigenesis. Topics addressed include neuronal differentiation, and the use of neuronal repressor element 1 silencing transcription factor/neuron-restrictive silencer factor (REST/NRSF) in therapy interventions.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2000
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: When is a patient capable of consent? Mental health law and the nurse. Basic powers under the Mental Health Act
- Abstracts: Promotion of women in academic medicine: shatter the ceilings, polish the floors. The Plight of Academic Health Centers
- Abstracts: Isolation of an unusual fungus in treated dental unit waterlines. Coronary artery stents: review and patient-management recommendations
- Abstracts: "I had an abortion when I was six months pregnant". Women living with AIDS. A hideous hate crime
- Abstracts: Alcohol consumption and mortality among middle-aged and elderly U.S. adults. Smoking vs Other Risk Factors as the Cause of Smoking-Attributable Deaths: Confounding in the Courtroom