Decreased CD127 expression on T cells in HIV-1-infected adults receiving antiretroviral therapy with or without intermittent IL-2 therapy
Article Abstract:
The interleukin-7 (IL-7)/IL-7 receptor [alpha] (IL-7R[alpha]) system is evaluated in a large cohort of HIV-infected patients, including a subset treatment with intermittent IL-2 and a multivariate regression models are used to determine predictors of CD127 expression. The results have shown that CD127 expression on T cells remain low in HIV-infected patients despite antiretroviral therapy, reflecting persistent aberration in the subset composition of the T-cell pool.
Publication Name: Journal of Acquired Immune Deficiency Syndromes (1999)
Subject: Health
ISSN: 1525-4135
Year: 2006
User Contributions:
Comment about this article or add new information about this topic:
When to start therapy for HIV infection: a swinging pendulum in search of data
Article Abstract:
Doctors continue to design clinical trials to determine when to begin treating HIV patients. Some doctors believe HIV patients should start taking AIDS drugs as soon as they are diagnosed. Other doctors believe in waiting until the patient's T cell count decreases. A study published in 2003 shows that immediate treatment may be beneficial, but the study was too small to prove this conclusively.
Publication Name: Annals of Internal Medicine
Subject: Health
ISSN: 0003-4819
Year: 2003
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Interferon-alpha with asymptomatic human immunodeficiency virus (HIV) infection: a randomized, placebo-controlled trial
- Abstracts: Zidovudine in asymptomatic human immunodeficiency virus infection: a controlled trial in persons with fewer than 500 CD4-Positive cells per cubic millimeter. part 2
- Abstracts: Zidovudine for early human immunodeficiency virus (HIV) infection: who, when, and how? Corticosteroids prevent early deterioration in patients with moderately severe pneumocystis carinii pneumonia and the acquired immunodeficiency syndrome (AIDS)
- Abstracts: The safety and efficacy of zidovudine (AZT) in the treatment of subjects with mildly symptomatic human immunodeficiency virus type 1 (HIV) infection. part 2
- Abstracts: Effect of knowledge of human immunodeficiency virus infection status on sexual activity among homosexual men. Marital status in relation to Kaposi's sarcoma, non-Hodgkin's lymphoma, and anal cancer in pre-AIDS era