Interleukin-1 expression by neutrophils in rheumatoid arthritis

Article Abstract:

The stimulation of interleukin-1 beta expression may occur in the general blood circulation before transportation to affected joints in patients with inflammatory joint diseases. Interleukin-1 beta is a protein involved in the inflammatory process. Researchers measured the levels of interleukin-1 beta in blood and synovial fluid samples from patients with rheumatoid arthritis (RA), ankylosing spondylitis, polyarthritis, psoriatic arthritis, and Lyme's disease. They compared these levels with those found in samples from healthy blood donors stimulated with a natural inflammatory compound, granulocyte macrophage colony stimulating factor (GM-CSF). Interleukin-1 beta levels in the synovial fluid from the patients with rheumatoid arthritis and polyarthritis were only 0.1-2% of that found in the stimulated blood donor samples. The interleukin-1 beta expression was higher in the blood of RA patients as compared to the synovial fluid.

Interleukin-1

---

Receptor expression in synovial fluid neutrophils from patients with rheumatoid arthritis

Article Abstract:

Neutrophils in the joints of rheumatoid arthritis (RA) patients may be activated to release different substances that can damage the joints. A study compared the types of receptors on neutrophils from the joints and blood of RA patients to those on neutrophils from the blood of healthy individuals. While neutrophils from the blood of RA patients had the same types of receptors as neutrophils from the blood of healthy individuals, different types of receptors were found on the neutrophils from synovial fluid from the joints of RA patients. Approximately half of the neutrophils from the joints of RA patients had the Fc-gamma RI receptor. This receptor was not present on neutrophils from the blood of RA patients or healthy individuals. Its presence on neutrophils from synovial fluid indicates that the neutrophils have been activated.

---

Activation of neutrophils by soluble and insoluble immunoglobulin aggregates from synovial fluid of patients with rheumatoid arthritis

Article Abstract:

Immunoglobulin aggregates may play an important role in activating neutrophils in patients with rheumatoid arthritis (RA). Activated neutrophils are cells of the immune system that release enzymes and reactive forms of oxygen that can damage tissue. A study examined the activation of neutrophils from healthy individuals by soluble and insoluble immunoglobulin aggregates isolated from synovial fluid from RA patients. Soluble immunoglobulins only activated neutrophils that had been treated with granulocyte-macrophage colony stimulating factor (GM-CSF). Insoluble immunoglobulins activated neutrophils that had been treated with GM-CSF and those that had not been treated with GM-CSF.

Immunoglobulins

Similar abstracts:

• Abstracts: Prevalence and expression of photosensitivity in systemic lupus erythematosus. Expression of systemic lupus erythematosus in various ethnic Jewish Israeli groups
• Abstracts: Expression and localization of matrilysin, a matrix metalloproteinase, in human endometrium during the reproductive cycle
• Abstracts: Assessment of cerebral hemodynamics in pregnant women by internal carotid artery pulsed Doppler velocimetry. Effect of early pregnancy on maternal regional cerebral blood flow
• Abstracts: Clinical characteristics and outcome of twin gestation complicated by preterm premature rupture of the membranes
• Abstracts: Gestational diabetes alters human placental vascular responses to changes in oxygen tension. A comparison opf rapid amniotic fluid markers in the prediction of microbial invasion of the uterine cavity and preterm delivery

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.