Introduction

Article Abstract:

The effectiveness of the quinolone antibiotics in treating infections in gynecologic patients was the topic of a recent symposium. Several studies show that the quinolone antibiotic ofloxacin is effective and in some cases the preferred antibiotic for treating gynecologic infection. Ofloxacin is active against the bacteria Neisseria gonorrhoeae and the yeast Candida trachomatis. It is also effective against gram-negative, facultative, anaerobic bacteria and gram positive aerobes. Ofloxacin shows some antimicrobial activity against Mycoplasma hominis and Ureaplasma urealyticum. However, quinolones are generally ineffective in treating soft tissue infections, such as pelvic inflammatory disease caused by obligate anaerobic bacteria. Studies have shown that the quinolones, including ofloxacin, are effective in treating urinary tract infections, skin and soft tissue infections, and infections of the lung. The studies presented at the symposium provide evidence that ofloxacin is effective in treating female pelvic infections caused by N. gonorrhoeae and C. trachomatis. Initial reports suggest that ofloxacin is also effective in treating some cases of pelvic inflammatory disease. (Consumer Summary produced by Reliance Medical Information, Inc.)

Evaluation, Drug therapy, Quinolone antibacterial agents, Fluoroquinolones, Pelvic inflammatory disease, Ofloxacin

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Immunoglobulin A response against Gardnerella vaginalis hemolysin and sialidase activity in bacterial vaginosis

Article Abstract:

Bacterial enzymes called sialidases may impair the local immune reaction against Garnerella vaginalis in bacterial vaginosis. Bacterial infections of the vagina often involve several bacterial species. Researchers evaluated vaginal bacterial activity in 131 healthy women, 72 women with bacterial vaginosis, and 19 women with Candida yeast infections of the vagina. Sialidase activity, associated with Prevotella and Bacteriodes species of bacteria, was detected in 75% of women with bacterial vaginosis, and was most common in women with no immune response to Garnerella bacteria.

Physiological aspects, Vaginosis, Candidiasis, Vulvovaginal, Vulvovaginal candidiasis

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