Effects of HIV infection on the serologic manifestations and response to treatment of syphilis in intravenous drug users

Article Abstract:

HIV infection in patients with syphilis does not appear to influence the symptoms, course of infection or response to treatment of the syphilis. Of 50 intravenous drug users with syphilis, 31 were HIV-positive and 19 were HIV-negative. The stage of syphilis at presentation did not differ with HIV status. Syphilis cases were no more severe among HIV patients than among those who were HIV negative. Twenty-six of the HIV-positive patients and 17 of the HIV-negative patients were treated with penicillin. All of the patients responded to treatment. Twelve of the HIV-positive patients took a higher than normal dose of penicillin, and there was no difference in response to treatment between those who took the standard dose and those who took the higher dose. There were no differences in the rates of syphilis relapse or reinfection between the two groups.

Complications and side effects, HIV infection, Drug therapy, HIV infections, Syphilis

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Use of the polymerase chain reaction for early detection of the proviral sequences of human immunodeficiency virus in infants born to seropositive mothers

Article Abstract:

A new test for AIDS virus infection can help detect the virus in very young infants. This used to be hard to do because the usual test for the virus works by detecting the specific kind of antibodies the body produces when it is infected with AIDS. Babies can have these antibodies, acquired from their mothers, in their blood without actually being infected with the virus. A new technique, the polymerase chain reaction, was tested on babies born to mothers with AIDS. Some of the babies born to these mothers ended up with AIDS and some did not. The test does not mistakenly detect AIDS in babies free of the virus. When the test is used on infants about five months old, it detects all infants who turn out to have AIDS and about a third of those who turn out to possibly but not definitely have AIDS.

Analysis, Diagnosis, Testing, HIV (Viruses), HIV, Comparative analysis, Infants (Newborn), Newborn infants, Disease transmission, Polymerase chain reaction, Blood chemical analysis, AIDS (Disease) in children, Pediatric AIDS (Disease), blood

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