Lapatinib plus capecitabine for HER2-positive advanced breast cancer

Article Abstract:

A phase 3, randomized, open-label study compared lapatinib plus capecitabine with capecitabine alone in women with progressive, human epidermal growth factor receptor type 2-positive (HER2-positive), locally advanced or metastatic breast cancer who were previously treated with a minimum of an anthracycline, a taxane, and trastuzumab. Results provide support for the use of lapatinib and capecitabine in women with progression of HER2-positive breast cancer after treatment with trastuzumab.

Dosage and administration, Trastuzumab, Clinical report, Lapatinib (Medication)

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Aromatase inhibitors in breast cancer

Article Abstract:

The clinical uses, benefits, and adverse effects of aromatase inhibitors for treating breast cancer are reviewed. This group of drugs inhibits the enzyme aromatase, which synthesizes estrogen from its precursor. This blocks the formation of estrogen, which stimulates the formation of breast cancer in some women. Some of the aromatase inhibitors are more effective than tamoxifen.

Evaluation, Aromatase inhibitors

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A comparison of letrozole and tamoxifen in postmenopausal women with early breast cancer

Article Abstract:

A comparison of letrozole with tamoxifen as adjuvant for steroid-hormone-receptor-positive breast cancer in postmenopausal women is presented. In postmenopausal women with endocrine-responsive breast cancer, adjuvant treatment with letrozole, as compared with tamoxifen, reduced the risk of recurrent disease, especially at distant sites.

England, Health aspects, Usage, Comparative analysis, Postmenopausal women, Tamoxifen, Letrozole

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