Long-Term persistence of primary genotypic resistance after HIV-1 serconversion

Article Abstract:

The drug resistance-associated mutations that persisted over time in the fourteen patients who experienced primary infection with genotypic evidence of resistance, which were followed for up to 3 years is studied. The study concludes that certain resistance-associated mutations are highly stable and these data support the recommendation that all new HIV diagnoses in areas where primary resistance occurs and should undergo genotyping irrespective of whether the date of seroconversion is known.

Physiological aspects, HIV infection, HIV infections, Genetic aspects, Drug resistance

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Highly active antiretroviral therapy interruption: Predictors and virologic and immunologic consequences

Article Abstract:

Concerted Action on Seroconversion to AIDS and Death in Europe data is used to characterize the magnitude and the predictors of highly active antiretroviral therapy (HAART) interruption (TI) and to investigate its immunologic and virologic consequences. The results have estimated that almost 1 in 6 subjects on HAART interrupt treatment by 2 years and have identified characteristics of subjects with the greatest risk for CD4 loss in whom TI might have greater risks.

Science & research, Health aspects, Research, Prognosis, Drug therapy, AIDS (Disease), CD4 lymphocytes, Highly active antiretroviral therapy

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